{"id":2826,"date":"2023-10-18T02:59:58","date_gmt":"2023-10-18T02:59:58","guid":{"rendered":"http:\/\/drhimanshuyadav.com\/f-hb-concentration-in-fit-may-stratify-colorectal-cancer-risk-in-the-elderly\/"},"modified":"2023-10-18T02:59:58","modified_gmt":"2023-10-18T02:59:58","slug":"f-hb-concentration-in-fit-may-stratify-colorectal-cancer-risk-in-the-elderly","status":"publish","type":"post","link":"https:\/\/drhimanshuyadav.com\/blog\/f-hb-concentration-in-fit-may-stratify-colorectal-cancer-risk-in-the-elderly\/","title":{"rendered":"F-Hb concentration in FIT may stratify colorectal cancer risk in the elderly"},"content":{"rendered":"<div id=\"article-content\">\n<h3 class=\"sectionTitle\">    Top line: <\/h3>\n<p>People over 75 years old (there is no upper age limit) <a class=\"cl_ref_article_2500006\" href=\"https:\/\/emedicine.medscape.com\/article\/2500006-overview\" target=\"_blank\" rel=\"noopener\">colorectal cancer<\/a> [CRC]    Screening) People with a negative fecal immunochemical test (FIT) but with detectable fecal hemoglobin (f-Hb) concentrations at last screening are more likely to have CRC than those without detectable f-Hb concentrations. from the Netherlands, where research suggests they are almost five times more likely to develop .<\/p>\n<h3 class=\"sectionTitle\">    methodology: <\/h3>\n<ul>\n<li>\n<p>Researchers assessed whether interval CRC risk differed by f-Hb concentration at last FIT.<\/p>\n<\/li>\n<li>\n<p>Individuals with a negative FIT (< 47 \u03bcg Hb\/g feces) at the last CRC screening round were checked for CRC diagnosis within 24 months of negative FIT.<\/p>\n<\/li>\n<li>\n<p>Interval CRC risk was assessed using survival analysis and Cox proportional hazards analysis.<\/p>\n<\/li>\n<li>\n<p>Stage distribution was determined using multivariable logistic regression analysis.<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"sectionTitle\">    remove: <\/h3>\n<ul>\n<li>\n<p>A total of 305,761 people participated in the study, and 661 cases of colorectal cancer were found.<\/p>\n<\/li>\n<li>\n<p>The overall interval CRC risk per 10,000 negative FIT tests was 21.6. In patients with previous f-HB concentrations > 0 \u03bcg\/g, it was 65.8 (<em>P<\/em> < .001). <\/p>\n<\/li>\n<li>\n<p>Patients with previous concentrations >0 \u03bcg\/g had a hazard ratio of 4.86 for interval CRC and an odds ratio of 1.45 for advanced-stage CRC compared with those without.<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"sectionTitle\">    in fact: <\/h3>\n<p>Researchers conclude that risk-stratified age limits for colorectal cancer screening based on past f-Hb concentrations may prevent colorectal cancer cases and colorectal cancer-related morbidity. ing. However, while people with detectable f-Hb may benefit from additional screening, screening in the elderly population is not without harm, and the harm-benefit ratio should be assessed and the optimal The researchers note that further research is needed to identify screening scenarios.<\/p>\n<h3 class=\"sectionTitle\">    sauce: <\/h3>\n<p>This data was presented at European Union Gastroenterology (UEG) Week 2023.<em>. <\/em>The study was led by Dr. Esther Toes-Zoutendijk from the Department of Public Health, Rotterdam University Medical Center, ERASMUS MC, Rotterdam, The Netherlands. <\/p>\n<h3 class=\"sectionTitle\">    Limitations: <\/h3>\n<p>Study authors reported no limitations.<\/p>\n<h3 class=\"sectionTitle\">    Disclosure: <\/h3>\n<p>Study authors report no relevant financial relationships. <\/p>\n<p>Unified European Gastroenterology (UEG) Week 2023: Summary of LB08.  Announced on October 16, 2023.<\/p>\n<p><em>For more news, follow Medscape <a href=\"https:\/\/www.facebook.com\/medscape\/\" target=\"_blank\" rel=\"noopener\">Facebook<\/a>, <a href=\"https:\/\/twitter.com\/Medscape\" target=\"_blank\" rel=\"noopener\">X<\/a>, <a href=\"https:\/\/www.instagram.com\/medscape\/?hl=en\" target=\"_blank\" rel=\"noopener\">Instagram<\/a>and <a href=\"https:\/\/www.youtube.com\/user\/medscape\" target=\"_blank\" rel=\"noopener\">YouTube<\/a> <\/em> <\/p>\n<\/p><\/div>\n<div id=\"legal_block\">\n      <bkmtr-front xmlns:dctm=\"https:\/\/www.documentum.com\" xmlns:fmt=\"https:\/\/java.sun.com\/jstl\/fmt\" xmlns:jsp=\"jsp\"><\/bkmtr-front><br \/>\n      <bkmtr-last xmlns:dctm=\"https:\/\/www.documentum.com\" xmlns:fmt=\"https:\/\/java.sun.com\/jstl\/fmt\" xmlns:jsp=\"jsp\"> <\/p>\n<p>credit:<br \/>Lead image: Paul Maguire\/Dreamstime<\/p>\n<p>      <\/bkmtr-last><\/p>\n<p>Medscape Medical News \u00a9 2023 WebMD, LLC<\/p>\n<p xmlns:dctm=\"https:\/\/www.documentum.com\" xmlns:fmt=\"https:\/\/java.sun.com\/jstl\/fmt\" xmlns:jsp=\"jsp\">Send comments and news tips to news@medscape.net.<\/p>\n<p id=\"citation\">\n       <!--news-->To quote this: F-Hb concentrations in otherwise negative FIT may help stratify colorectal cancer risk in elderly populations &#8211; <i>medscape<\/i> &#8211; October 16, 2023.<\/p>\n<\/p><\/div>\n<p><script async src=\"\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><script async src=\"\/\/www.instagram.com\/embed.js\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Top line: People over 75 years old (there is no upper age limit) colorectal cancer [CRC] Screening) People with a negative fecal immunochemical test (FIT) but with detectable fecal hemoglobin (f-Hb) concentrations at last screening are more likely to have CRC than those without detectable f-Hb concentrations. from the Netherlands, where research suggests they are &#8230; <a title=\"F-Hb concentration in FIT may stratify colorectal cancer risk in the elderly\" class=\"read-more\" href=\"https:\/\/drhimanshuyadav.com\/blog\/f-hb-concentration-in-fit-may-stratify-colorectal-cancer-risk-in-the-elderly\/\" aria-label=\"Read more about F-Hb concentration in FIT may stratify colorectal cancer risk in the elderly\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":2827,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[175],"tags":[3,24,1839,1343,1840,1841,36,1842],"class_list":["post-2826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anal-cancer","tag-cancer","tag-colorectal","tag-concentration","tag-elderly","tag-fhb","tag-fit","tag-risk","tag-stratify"],"_links":{"self":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/2826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/comments?post=2826"}],"version-history":[{"count":0,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/2826\/revisions"}],"wp:attachment":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/media?parent=2826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/categories?post=2826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/tags?post=2826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}