{"id":2841,"date":"2023-10-19T19:53:18","date_gmt":"2023-10-19T19:53:18","guid":{"rendered":"http:\/\/drhimanshuyadav.com\/weight-loss-has-no-negative-impact-on-the-quality-of-life-of-colorectal-cancer-patients\/"},"modified":"2023-10-19T19:53:18","modified_gmt":"2023-10-19T19:53:18","slug":"weight-loss-has-no-negative-impact-on-the-quality-of-life-of-colorectal-cancer-patients","status":"publish","type":"post","link":"https:\/\/drhimanshuyadav.com\/blog\/weight-loss-has-no-negative-impact-on-the-quality-of-life-of-colorectal-cancer-patients\/","title":{"rendered":"&#8216;Weight loss&#8217; has no negative impact on the quality of life of colorectal cancer patients"},"content":{"rendered":"<div data-component=\"ArticleContent\">\n<div class=\"article__content--header\">\n<div class=\"article__posted-date\">\n<p>    October 16, 2023 <\/p>\n<p>    2 minute read <\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"mobile-trust-box\">\n<div class=\"row\">\n<div class=\"col-12 col-md-5 d-xl-none\">\n<div class=\"trust-box\">\n<div class=\"trust-box-logo d-none d-md-block\">\n          <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/h5\/feature\/news\/publogos\/hot.svg?h=24&amp;w=141&amp;la=en&amp;hash=2F86D471C8514C0E334E329AA799E8B4\" height=\"24\" width=\"141\" class=\"logo-img\" alt=\"Hemonk today's logo\"\/>\n        <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"col-12 col-md-6 offset-md-1 offset-xl-0 col-xl-12\">\n<div class=\"d-none\" data-component=\"EmailTopicAlert\" data-module=\"Subspecialty Email Topic Alerts Top\" data-manage-email-link=\"\/footer\/account-information\/my-account\/email-subscriptions-and-alerts#emailAlerts\">\n  <hidden data-setting-item=\"d265901d-6d37-49c7-a8f6-c7bf19a02509\"\/><br \/>\n  <hidden data-crm-source=\"Subspecialty Topic Alert\"\/><\/p>\n<div class=\"email-alert-button d-none\" data-topic-button=\"not-subscribed\">\n<p>&#13;<br \/>\n      <span data-module-track-action=\"Email Alerts TOP_Click_Healio News Article\" data-module-track-label=\"Email Alerts TOP_Healio News Article\">&#13;<br \/>\n        <i class=\"fas fa-plus-circle\"\/>Add topics to email alerts<br \/>\n      <\/span>&#13;\n    <\/p>\n<div class=\"email-alert-inner collapse uf5d2824ee76048d0ae9db646d3c00adf\">\n<div class=\"email-alert-dialogue\">\n<p>Receive an email when a new article is posted <span data-content=\"topic-title\"\/>&#13;\n        <\/p>\n<div class=\"d-none\" data-sign-up-type=\"unknown\">\n<p>          Enter your email address to receive emails when new articles are posted. <span data-content=\"topic-title\"\/>.<\/p><\/div>\n<\/p><\/div>\n<p>      <button type=\"button\" class=\"btn btn-primary\" data-loading-text=\"Loading &lt;i class=\" fa=\"\" fa-spinner=\"\" fa-spin=\"\">&#8221; data-action=&#8221;subscribe&#8221;> Subscribe<br \/>\n      <\/button>\n    <\/div>\n<\/p><\/div>\n<div class=\"d-none\" data-topic-modal=\"failed\">    <strong>Your request could not be processed. Please try again later. If you continue to experience this issue, please contact us at customerservice@slackinc.com.<\/strong>  <\/p>\n<p><button data-dismiss=\"modal\" class=\"btn btn-primary btn-lg btn-block\">Return to Helio<\/button><\/p>\n<\/div>\n<\/div><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<h4>Important points:<\/h4>\n<ul>\n<li>Weight loss and systemic therapy did not result in statistically significant differences in health-related quality of life.<\/li>\n<li>Serious adverse events occurred in twice as many patients assigned to the reduced dose regimen.<\/li>\n<\/ul>\n<p>Study results show that weight loss combined with standard systemic therapy did not significantly impact overall quality of life in a cohort of patients with metastatic colorectal cancer<em>.<\/em><\/p>\n<p>Survey results \u2014 Published in <em>Journal of the National Comprehensive Cancer Network<\/em> The researchers also concluded that patients assigned to the weight loss intervention had twice as many serious adverse events as patients in the standard treatment group.<\/p>\n<figure class=\"figure article__og-image\">&#13;\n    <picture>&#13;<source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.webp?w=476\" media=\"(max-width: 768px)\">&#13;<source srcset=\"https:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.webp?w=800\" media=\"(max-width: 992px)\">&#13;<source srcset=\"https:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.webp?w=595\" media=\"(max-width: 1200px)\">&#13;<source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.webp?w=476\" media=\"(min-width: 1200px)\">&#13;<source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.webp?w=476\">&#13;<br \/>\n&#13;<br \/>\n      <img decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/slack-news\/hemonc\/misc\/infographics\/hot-infographics\/2023\/10_october\/hot1023bakkerus_ig14_web.jpg?w=800\" alt=\"Infographic of serious treatment-related adverse event rates\" class=\"figure-img img-fluid\" width=\"800\"\/>&#13;<br \/>\n    <\/source><\/source><\/source><\/source><\/source><\/picture>&#13;<figcaption class=\"figure-caption\">Data obtained from Bakkerus L et al. <em>J Natl Compr Canc Netw. <\/em>2023;doi:10.6004\/jnccn.2023.7050<br \/>\n    <\/figcaption>&#13;<br \/>\n  <\/figure>\n<h4>Rationale and methodology<\/h4>\n<p>\u201cMaintaining an adequate health-related quality of life is important in the palliative treatment of patients with metastatic colorectal cancer.\u201d <strong>Lotte <\/strong><strong>Buckels<\/strong><strong>medical doctor,<\/strong> Researchers from the Department of Medical Oncology at the Radboud Institute for Health Sciences in the Netherlands and their colleagues wrote.<\/p>\n<div class=\"mug left\"><img loading=\"lazy\" decoding=\"async\" height=\"106\" alt=\"Lotte Buckels, Maryland\" width=\"80\" src=\"https:\/\/www.healio.com\/news\/hematology-oncology\/20231016\/~\/media\/8fd06e9a96b5498996d87cae057283e7.ashx\"\/><\/p>\n<p><strong>Lotte Buckels<\/strong><\/p>\n<\/div>\n<p>Researchers studied 300 patients with multisystem metastatic colorectal cancer who received either cytoreduction and first-line palliative systemic therapy (n = 148) or standard systemic therapy alone (n = 148). We sought to prospectively evaluate the OS benefit and impact on health-related quality of life by randomly assigning patients to patients with cancer.  152).<\/p>\n<h4>Investigation result<\/h4>\n<p>Results showed no statistically significant differences in health-related quality of life or fatigue between patients assigned weight loss and systemic therapy and those assigned standard systemic therapy alone. <\/p>\n<p>The researchers further observed that there were no significant differences in health-related quality of life in both treatment groups after one year of treatment.  <\/p>\n<p>However, results showed that patients assigned dose reduction and systemic therapy had twice the rate of serious adverse events (<em>P<\/em> \u2264 .001). Researchers observed serious adverse events in 21% of patients assigned standard systemic therapy, compared with 43% of patients assigned a reduced-dose regimen. <\/p>\n<p>&#8220;This may mean that the negative impact on quality of life from complications is temporary and is eventually balanced out by a reduction in tumor-related symptoms after treatment,&#8221; Dr. Buckels said. stated in a press release.  &#8220;Patients may also adapt their perceptions of health-related quality of life over the course of illness and treatment.&#8221;<\/p>\n<h4>Future research <\/h4>\n<p>\u201cGiven the significant amount of complications associated with local treatment, we expected to see a greater impact on overall and durable quality of life in the experimental group,\u201d Buckels said in the release. . &#8220;The fact that the severe side effects associated with topical therapy did not lead to a significant reduction in patients&#8217; perceived quality of life is very interesting and warrants further investigation. These results, including the risks, [for] Comorbidities must be considered in the office to determine together with the patient the appropriate treatment for each individual.  \u201d<\/p>\n<h4>      <strong>References:<\/strong>    <\/h4>\n<div class=\"publisher-logo\">\n    <span>Issuer:<\/span><br \/>\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/h5\/feature\/news\/publogos\/hot.svg?h=24&amp;w=141&amp;la=en&amp;hash=2F86D471C8514C0E334E329AA799E8B4\" class=\"logo-img\" width=\"141\" height=\"24\" alt=\"Hemonk today's logo\"\/>\n  <\/div>\n<div class=\"sources-disclosures\">\n  <a class=\"title\" data-toggle=\"collapse\" data-target=\".sources-disclosures-toggle\" aria-controls=\"sources-disclosures-content\">Information source\/disclosure information<i class=\"fas\"\/><\/p>\n<p class=\"collapse-label show\">collapse<\/p>\n<p>&#13;<br \/>\n  <\/a><\/p>\n<div id=\"sources-disclosures-content\" class=\"sources-disclosures-toggle collapse show\">\n<p>&#13;<br \/>\n        <strong> Disclosure: <\/strong>Blokker-Verwer, KWF Kankerbestrijding, and Roche Nederland supported the research. None of the authors report relevant financial disclosures.\n      <\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"article__content--footer\">\n<div class=\"d-none\" data-component=\"EmailTopicAlert\" data-module=\"Subspecialty Email Topic Alerts Top\" data-manage-email-link=\"\/footer\/account-information\/my-account\/email-subscriptions-and-alerts#emailAlerts\">\n  <hidden data-setting-item=\"d265901d-6d37-49c7-a8f6-c7bf19a02509\"\/><br \/>\n  <hidden data-crm-source=\"Subspecialty Topic Alert\"\/><\/p>\n<div class=\"email-alert-button d-none\" data-topic-button=\"not-subscribed\">\n<p>&#13;<br \/>\n      <span data-module-track-action=\"Email Alerts TOP_Click_Healio News Article\" data-module-track-label=\"Email Alerts TOP_Healio News Article\">&#13;<br \/>\n        <i class=\"fas fa-plus-circle\"\/>Add topics to email alerts<br \/>\n      <\/span>&#13;\n    <\/p>\n<div class=\"email-alert-inner collapse uf5d2824ee76048d0ae9db646d3c00adf\">\n<div class=\"email-alert-dialogue\">\n<p>Receive an email when a new article is posted <span data-content=\"topic-title\"\/>&#13;\n        <\/p>\n<div class=\"d-none\" data-sign-up-type=\"unknown\">\n<p>          Enter your email address to receive emails when new articles are posted. <span data-content=\"topic-title\"\/>.<\/p><\/div>\n<\/p><\/div>\n<p>      <button type=\"button\" class=\"btn btn-primary\" data-loading-text=\"Loading &lt;i class=\" fa=\"\" fa-spinner=\"\" fa-spin=\"\">&#8221; data-action=&#8221;subscribe&#8221;> Subscribe<br \/>\n      <\/button>\n    <\/div>\n<\/p><\/div>\n<div class=\"d-none\" data-topic-modal=\"failed\">    <strong>Your request could not be processed. 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