{"id":2855,"date":"2023-10-20T20:10:48","date_gmt":"2023-10-20T20:10:48","guid":{"rendered":"http:\/\/drhimanshuyadav.com\/ctdna-assay-detects-colorectal-cancer-in-blood\/"},"modified":"2023-10-20T20:10:48","modified_gmt":"2023-10-20T20:10:48","slug":"ctdna-assay-detects-colorectal-cancer-in-blood","status":"publish","type":"post","link":"https:\/\/drhimanshuyadav.com\/blog\/ctdna-assay-detects-colorectal-cancer-in-blood\/","title":{"rendered":"ctDNA assay detects colorectal cancer in blood"},"content":{"rendered":"<div>\n<p>Circulating tumor DNA (ctDNA) assays can detect colorectal cancer (CRC) in blood samples with high specificity and sensitivity, according to a study published in . <em>Annals of Oncology.<\/em><\/p>\n<p>ctDNA assays integrate genomics, epigenomics, and fragment-omics. The researchers tested the assay using blood samples taken from two groups of patients.<\/p>\n<p>The first group consisted of 318 patients who participated in a CRC screening program and had a positive fecal immunochemical test (FIT) result. She was the only one of these patients who was ultimately diagnosed with colorectal cancer.<\/p>\n<p><!--sse--><!--\/sse--><\/p>\n<hr\/>\n<p><span class=\"text\">Continue reading<\/span><\/p>\n<p>The second group consisted of 322 patients who were diagnosed with CRC and provided a blood sample before treatment.<\/p>\n<p>The sensitivity of the assay to detect CRC was 93% and the specificity was 90%. In comparison, the researchers noted that fecal occult blood testing using FIT or multitargeted fecal DNA achieved specificity of 86.6% to 94.9%. Although colonoscopy is more specific, the procedure is more invasive, more expensive and carries a risk of complications, they added.<\/p>\n<p>The sensitivity of the ctDNA assay depends on the TNM stage. Sensitivity was 84% \u200b\u200bfor stage I, 94% for stage II, and 96% for stage III (<em>P <\/em><.024). The test detected all Stage IV cases, but only two cases.<\/p>\n<p>&#8220;[T]&#8221;The results of this proof-of-concept study demonstrate the clinical validity of a new multimodal blood-based assay with high accuracy standards,&#8221; the researchers wrote.<\/p>\n<p>The researchers added that the test could improve adherence to colorectal cancer screening and screening accuracy, but further studies in larger cohorts are needed.<\/p>\n<p><em>Disclosure: Some study authors declared affiliations with biotechnology, pharmaceutical, and\/or device companies. Please refer to the original reference material for a complete list of disclosures. <\/em><strong\/><\/p>\n<p>reference<br \/>Bessa X, Vidal J, Balboa JC, et al. <a href=\"https:\/\/www.annalsofoncology.org\/article\/S0923-7534(23)04010-3\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">High accuracy of blood ctDNA-based multimodal test for detecting colorectal cancer<\/a>. <em>Chronicle Oncor. <\/em>Published online on October 5, 2023.  doi:10.1016\/j.annonc.2023.09.3113<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Circulating tumor DNA (ctDNA) assays can detect colorectal cancer (CRC) in blood samples with high specificity and sensitivity, according to a study published in . Annals of Oncology. ctDNA assays integrate genomics, epigenomics, and fragment-omics. The researchers tested the assay using blood samples taken from two groups of patients. The first group consisted of 318 &#8230; <a title=\"ctDNA assay detects colorectal cancer in blood\" class=\"read-more\" href=\"https:\/\/drhimanshuyadav.com\/blog\/ctdna-assay-detects-colorectal-cancer-in-blood\/\" aria-label=\"Read more about ctDNA assay detects colorectal cancer in blood\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":2856,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[1860,528,3,24,1861,1862],"class_list":["post-2855","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colorectal-cancer","tag-assay","tag-blood","tag-cancer","tag-colorectal","tag-ctdna","tag-detects"],"_links":{"self":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/2855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/comments?post=2855"}],"version-history":[{"count":0,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/2855\/revisions"}],"wp:attachment":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/media?parent=2855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/categories?post=2855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/tags?post=2855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}