{"id":3836,"date":"2024-02-12T21:28:33","date_gmt":"2024-02-12T21:28:33","guid":{"rendered":"http:\/\/drhimanshuyadav.com\/newly-identified-biomarkers-could-slow-disease-spread\/"},"modified":"2024-02-12T21:28:33","modified_gmt":"2024-02-12T21:28:33","slug":"newly-identified-biomarkers-could-slow-disease-spread","status":"publish","type":"post","link":"https:\/\/drhimanshuyadav.com\/blog\/newly-identified-biomarkers-could-slow-disease-spread\/","title":{"rendered":"Newly identified biomarkers could slow disease spread"},"content":{"rendered":"<div id=\"\">\n<div class=\"css-1u22pos\"><span style=\"font-size:0;line-height:0\"\/><span style=\"font-size:0;line-height:0\"\/><\/p>\n<div>\n<figure class=\"css-z8zrn2\"><span class=\"css-rwmw5v\"><span class=\"css-tx1uqz\"><picture class=\"css-16pk1is\"><source srcset=\"https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/sites\/3\/2024\/02\/female-smiling-cancer-doctor-1296x728-header-1024x576.jpg 750w\" media=\"(min-width: 1190px)\"\/><source srcset=\"https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/sites\/3\/2024\/02\/female-smiling-cancer-doctor-1296x728-header-1024x576.jpg 750w\" media=\"(min-width: 990px)\"\/><source srcset=\"https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/sites\/3\/2024\/02\/female-smiling-cancer-doctor-1296x728-header-1024x576.jpg 879w\" media=\"(min-width: 768px)\"\/><img decoding=\"async\" src=\"https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/sites\/3\/2024\/02\/female-smiling-cancer-doctor-1296x728-header-1024x576.jpg\" alt=\"Female cancer patient smiling in the examination room \" class=\"css-1jytyml\"\/><\/picture><\/span><hl-share-overlay class=\"css-18moxll\"><span class=\"css-8yl26h\">Share on Pinterest<\/span><\/hl-share-overlay><\/span><figcaption class=\"css-1wtn3ae\">Researchers have identified an immune system protein, Ku70, that can be used as a biomarker for colon cancer screening and treatment.Enigma Images\/Getty Images<\/figcaption><\/figure>\n<\/div>\n<ul>\n<li><strong>Bowel cancer, or colon cancer, is currently the third most common cancer in the world. <\/strong><\/li>\n<li><strong>Cases of colon cancer among young adults are increasing in many parts of the world.<\/strong><\/li>\n<li><strong>Colorectal cancer screening is important for early detection of the disease.<\/strong><\/li>\n<li><strong>Researchers have identified a protein in the immune system that can be used as a biomarker during colon cancer screening and may slow the progression of the disease.<\/strong><\/li>\n<\/ul>\n<p>Colorectal cancer (also known as colorectal cancer or colon cancer) is currently <hl-trusted-source source=\"World Health Organization\" rationale=\"Highly respected international organization\"><a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/colorectal-cancer\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">3rd most common cancer<\/a><\/hl-trusted-source>    In the world. <\/p>\n<p>Although it is colon cancer, <hl-trusted-source source=\"American Cancer Society\" rationale=\"Highly respected international organization\"><a href=\"https:\/\/www.cancer.org\/cancer\/types\/colon-rectal-cancer\/treating\/by-stage-colon.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">treatable<\/a><\/hl-trusted-source>    Only if caught in the early stages, <hl-trusted-source source=\"National Cancer Institute \" rationale=\"Governmental authority\"><a href=\"https:\/\/seer.cancer.gov\/statfacts\/html\/colorect.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">Approximately 35%<\/a><\/hl-trusted-source>    All cases are diagnosed at an early stage. <\/p>\n<p>Previous studies have shown that colon cancer recurrence occurs in 30 to 40 percent of people treated for this type of cancer. <\/p>\n<p>For this reason, <hl-trusted-source source=\"National Cancer Institute \" rationale=\"Governmental authority\"><a href=\"https:\/\/www.cancer.gov\/types\/colorectal\/patient\/colorectal-screening-pdq\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">Colorectal cancer screening<\/a><\/hl-trusted-source>    Important for early detection of cancer. <\/p>\n<p><strong>Australian National University researchers are helping to provide additional biomarkers that can be used in the future to improve outcomes at all stages of disease spread. <\/strong><\/p>\n<p>Manipulating this particular protein in the immune system, Ku70, could potentially treat colon cancer.The results of this study were recently published in the journal <a rel=\"noopener noreferrer\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adh3409\" target=\"_blank\" class=\"content-link css-1pg8eb5\"><em>scientific progress<\/em><\/a>.<\/p>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"\/><span style=\"font-size:0;line-height:0\"\/><\/p>\n<p><a rel=\"noopener noreferrer\" href=\"https:\/\/researchers.anu.edu.au\/researchers\/man-sm\" target=\"_blank\" class=\"content-link css-1pg8eb5\">Dr. Shi Min Man<\/a>group leader in the Department of Immunology and Infectious Diseases at the Australian National University, CSL Centenary Fellow and corresponding author of the study, said he hopes researchers will continue to explore new treatments for bowel cancer. explained why it is important. <\/p>\n<p>\u201cDespite progress in developing new treatments, colorectal cancer remains the most important disease. [third] &#8220;It is the leading cause of cancer-related deaths worldwide,&#8221; said Dr. Mann. <em>Today&#8217;s medical news<\/em>. <\/p>\n<p>\u201cEspecially given the high mortality rate and increasing incidence. <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10729308\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">Young population<\/a><\/hl-trusted-source> [adults under 50]    \u2014 Patients with colorectal cancer need improvements to existing treatments and the development of more effective and safer treatments.  \u201d<\/p>\n<p><strong>The researchers found that approx. <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8273208\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">1.93 <\/a><\/hl-trusted-source><hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8273208\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">a million<\/a><\/hl-trusted-source>    The number of colorectal cancer cases worldwide in 2020 is expected to reach 3.2 million in 2040. <\/strong><\/p>\n<p>Cases of colorectal cancer among young people are also increasing in many parts of the world, including the United States, United Kingdom, Europe, and China. <\/p>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"\/><span style=\"font-size:0;line-height:0\"\/><\/p>\n<p>When asked why he decided to look for immune system proteins as a way to help prevent and even treat colorectal cancer, Dr. Mann said scientists have long known that the immune system can find and destroy cancer cells. He said he knew. <\/p>\n<p>&#8220;Harnessing and enhancing the power of the immune system may therefore be a safe approach to limit cancer development,&#8221; Dr. Mann explained.<\/p>\n<p>\u201cThis vision led to the identification of remarkable immune proteins that can guide therapeutic decisions for colorectal cancer patients.\u201d<\/p>\n<p><strong>For this study, Dr. Mann and his team focused on a protein called . <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8073936\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">70<\/a><\/hl-trusted-source>.<\/strong><\/p>\n<p>&#8220;Ku70 is an immune protein that acts as a repair agent, repairing breaks and damage to the instruction manual called DNA,&#8221; Dr. Mann explained. <\/p>\n<blockquote class=\"css-34gtoi\">\n<p>\u201cIn this study, we observed that colorectal cancer patients have less Ku70 protein in their bodies and are more likely to die from the disease early in life. Our results suggest that it can be used as a biomarker in predicting cancer.<\/p>\n<p>They also observed that Ku70 acts like a surveillance system to detect damaged DNA, working in conjunction with other immune proteins. <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a rel=\"noopener noreferrer\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5555610\/\" target=\"_blank\" class=\"content-link css-1pg8eb5\">Russ<\/a><\/hl-trusted-source>    and <hl-trusted-source source=\"Nature\" rationale=\"Highly respected journal,Expert written journal,Peer reviewed journal\"><a rel=\"noopener noreferrer\" href=\"https:\/\/www.nature.com\/articles\/nrm3979\" target=\"_blank\" class=\"content-link css-1pg8eb5\">rough<\/a><\/hl-trusted-source>In colorectal cancer, healthy cells frequently change to prevent them from turning into cancer cells.  \u201d<\/p>\n<p>\u2014 Dr. Si Ming Man, corresponding study author<\/p>\n<\/blockquote>\n<p>Looking to the future, Dr. Mann will study the precise origins and characteristics of the DNA involved in Ku70-mediated activation of Ras and Raf to guide the development of new treatments and improve inflammatory diseases and cancer. He said it has the potential to improve the therapeutic outcomes of therapeutic drugs.<\/p>\n<p>&#8220;A potential future direction of this research is to test whether Ku70 functions similarly in other cancers,&#8221; he added.  &#8220;Studies that activate his Ku70 using small molecule drugs and\/or DNA-based treatments are another potential avenue.&#8221;<\/p>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"\/><span style=\"font-size:0;line-height:0\"\/><\/p>\n<p><em>MNT<\/em> I also talked to <a href=\"https:\/\/www.providence.org\/doctors\/surgical-oncology\/ca\/santa-monica\/anton-bilchik-1609916733\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">Dr. Anton Bilchik<\/a>John, a surgical oncologist, medical director, and director of the gastrointestinal-hepatobiliary program at St. John&#8217;s Cancer Institute in Santa Monica, California, spoke about the study. <\/p>\n<p>Dr. Bilchik said he found this study exciting and provocative because it identified a specific signaling pathway within cells that, if suppressed, promotes the progression of cells that can lead to colon cancer. <\/p>\n<p>&#8220;And when certain mutations or expression of these genes increases, the opposite happens,&#8221; he added. <\/p>\n<p>\u201cTherefore, the relevance of these findings is that they identify specific signaling pathways that could be targeted for treatment of colorectal cancer.\u201d<\/p>\n<p>&#8220;And we&#8217;re seeing an epidemic of colorectal cancer among young people, people under 50,&#8221; Dr. Bilchik continued. <\/p>\n<p><strong>&#8220;Thus, all the information that provides insight into the causes of colorectal cancer does not mean that this study merely suggests specific signals or pathways that may lead to colorectal cancer and inflammatory bowel disease. Yes, it is very important.\u201d<\/strong><\/p>\n<p><span class=\"css-zya54r\"\/><\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"\/><span style=\"font-size:0;line-height:0\"\/><\/p>\n<p>Dr. Bilchik said there are common themes around the world as to why colorectal cancer rates are rising among young people. <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7352519\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">obesity<\/a><\/hl-trusted-source>, <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8168576\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">alcohol<\/a><\/hl-trusted-source>and <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8879005\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1pg8eb5\">smoking<\/a><\/hl-trusted-source>.<\/p>\n<p>&#8220;And what has been noted is that in certain countries where alcohol consumption is decreasing, such as France and Italy, the number of young people diagnosed with colorectal cancer is stable or decreasing. That is,\u201d he elaborated. <\/p>\n<p>\u201cUnlike other countries, such as the UK and Scandinavia, where alcohol consumption is increasing, and we&#8217;re talking particularly among young adults, the incidence of early-onset colorectal cancer has increased compared to late-onset cancer. 50.  \u201d<\/p>\n<p>Dr. Bilchik said the next step in this research is to better define which specific cells are most relevant. <\/p>\n<blockquote class=\"css-34gtoi\">\n<p>&#8220;Two of the known causes of colorectal cancer are related to the microbiome, the bacteria in the body, and the immune system. So we need to further explore how this impacts the microbiome and immune microenvironment. Many studies have shown that. And the most interesting thing is to find out what drugs can enhance or decrease expression.&#8221;<\/p>\n<p>\u2014 Dr. Anton Bilchik, surgical oncologist<\/p>\n<\/blockquote>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Share on PinterestResearchers have identified an immune system protein, Ku70, that can be used as a biomarker for colon cancer screening and treatment.Enigma Images\/Getty Images Bowel cancer, or colon cancer, is currently the third most common cancer in the world. Cases of colon cancer among young adults are increasing in many parts of the world. &#8230; <a title=\"Newly identified biomarkers could slow disease spread\" class=\"read-more\" href=\"https:\/\/drhimanshuyadav.com\/blog\/newly-identified-biomarkers-could-slow-disease-spread\/\" aria-label=\"Read more about Newly identified biomarkers could slow disease spread\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":3837,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[346,17,1201,2235,2233,1207],"class_list":["post-3836","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colorectal-cancer","tag-biomarkers","tag-disease","tag-identified","tag-newly","tag-slow","tag-spread"],"_links":{"self":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/3836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/comments?post=3836"}],"version-history":[{"count":0,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/posts\/3836\/revisions"}],"wp:attachment":[{"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/media?parent=3836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/categories?post=3836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drhimanshuyadav.com\/blog\/wp-json\/wp\/v2\/tags?post=3836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}