The microbiome plays a vital role in the proper functioning of the gastrointestinal and hepatobiliary systems. Its composition is influenced by many factors such as diet, lifestyle, drugs, and environment. The gut microbiota indirectly acts as a command center for the interaction between precision medicine and direct bacterial production, and mediating them with human immunity and energy homeostasis. Imbalances within the gut microbiome are associated with inflammatory bowel disease (IBD), Clostridioides difficile infection (CDI), non-alcoholic fatty liver disease (NAFLD), hepatic encephalopathy and cholangitis. Precision nutrition supports gastrointestinal and hepatobiliary health by promoting a balanced, nutrient-rich diet that supports microbiome growth and diversity. By tailoring nutritional plans to an individual’s unique needs and genetics, precision nutrition is an effective approach to promoting gastrointestinal and hepatobiliary health.

This special collection aims to collect papers on the microbiome in the context of gastrointestinal and hepatobiliary pathophysiology and the latest insights into how precision nutrition can optimize health and prevent or treat disease. The purpose is

Potential topics include, but are not limited to:

• The impact of precision nutrition on the gut microbiota and the development and progression of inflammatory bowel disease (IBD).
– The role of individualized nutritional interventions in the prevention and treatment of gastroesophageal reflux disease (GERD).
– The impact of a personalized diet on the composition and diversity of the gut microbiota in patients with irritable bowel syndrome (IBS).
• Relationship between gut microbiota and nutrient absorption in patients with malabsorptive diseases such as celiac disease.
-Efficacy of personalized nutritional interventions to improve gut microbiota diversity and reduce chronic inflammation in patients with gastrointestinal diseases.
• Use of precision nutrition in the prevention and treatment of gastrointestinal cancers.
• The impact of individualized nutritional interventions on the composition and function of the gut microbiome in patients undergoing gastrointestinal surgery.
• The role of the gut microbiota in the metabolism of drugs used to treat gastrointestinal diseases.
• Relationship between gut microbiota and liver diseases such as non-alcoholic fatty liver disease (NAFLD) and cirrhosis.

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