Top line:
Moderate doses of multivitamin supplements appear to reduce the risk of both all-cause and cancer-related death in patients with the following diseases: colorectal cancer (CRC); However, high-dose multivitamin supplements may increase the risk of colorectal cancer-specific death.
methodology:
- Some studies suggest that multivitamin supplements may increase the risk of colon cancer, and other studies suggest that certain components of vitamin C may multivitaminvitamins C and D, which may have anti-colon cancer effects.
- Because as many as half of CRC survivors take multivitamins, researchers wanted to assess whether multivitamin use affects overall survival in CRC patients.
- In the current prospective cohort study, researchers used detailed information obtained from patients in the Nurses’ Health Study and Health Professionals Follow-up Study to study 2,424 patients with stage I-III colorectal cancer. The use and dosage of multivitamin supplements was evaluated.
- Participants completed mailed surveys every two years. The survey included questions regarding current use of multivitamin supplements and weekly dosage (0, 1-2, 3-5, 6-9, and >10 tablets).
- Researchers evaluated the potential association between multivitamin use and colorectal cancer-related and all-cause mortality.
remove:
- During a median follow-up of 11 years, there were 1,512 deaths and 343 cancer deaths.
- For patients diagnosed with CRC, taking moderate doses of multivitamins (3 to 5 tablets per week) was associated with a lower risk of cancer-related mortality compared with no multivitamin use. decreased by 45% (adjusted hazard ratio). [aHR],0.55; P = .005).
- Moderate multivitamin use was also associated with a lower risk of all-cause mortality (aHR, 0.81; P = .04) as well as a high dose of 6 to 9 tablets per week (aHR, 0.79; P < .001).
- However, higher doses of 10 or more tablets per week were associated with a 60% increased risk of cancer-related death (aHR, 1.60; aHR, 1.60). P = .02).
in fact:
The results of this study suggest that moderate use of multivitamin supplements may have a survival benefit in patients with colorectal cancer, but higher doses do not. “Further research is needed before making clinical recommendations for the use of multivitamin supplements,” the authors said.
sauce:
The study was led by Ming-ming He of the Sun Yat-sen University Cancer Center in Guangzhou, China. cancer.
Limitations:
Given the observational design of the study, there is potential for residual confounding. Reverse causation and recall bias may also be limitations.
Disclosure:
This research was funded by the National Institutes of Health, the American Cancer Institute, Wellesley College, Dana-Farber Cancer Institute, and the Entertainment Industry Foundation. Three study authors reported financial relationships outside of this study.