F-Hb concentration in FIT may stratify colorectal cancer risk in the elderly

Top line:

People over 75 years old (there is no upper age limit) colorectal cancer [CRC] Screening) People with a negative fecal immunochemical test (FIT) but with detectable fecal hemoglobin (f-Hb) concentrations at last screening are more likely to have CRC than those without detectable f-Hb concentrations. from the Netherlands, where research suggests they are almost five times more likely to develop .

methodology:

• Researchers assessed whether interval CRC risk differed by f-Hb concentration at last FIT.

• Individuals with a negative FIT (< 47 μg Hb/g feces) at the last CRC screening round were checked for CRC diagnosis within 24 months of negative FIT.

• Interval CRC risk was assessed using survival analysis and Cox proportional hazards analysis.

• Stage distribution was determined using multivariable logistic regression analysis.

remove:

• A total of 305,761 people participated in the study, and 661 cases of colorectal cancer were found.

• The overall interval CRC risk per 10,000 negative FIT tests was 21.6. In patients with previous f-HB concentrations > 0 μg/g, it was 65.8 (P < .001).

• Patients with previous concentrations >0 μg/g had a hazard ratio of 4.86 for interval CRC and an odds ratio of 1.45 for advanced-stage CRC compared with those without.

in fact:

Researchers conclude that risk-stratified age limits for colorectal cancer screening based on past f-Hb concentrations may prevent colorectal cancer cases and colorectal cancer-related morbidity. ing. However, while people with detectable f-Hb may benefit from additional screening, screening in the elderly population is not without harm, and the harm-benefit ratio should be assessed and the optimal The researchers note that further research is needed to identify screening scenarios.

sauce:

This data was presented at European Union Gastroenterology (UEG) Week 2023.. The study was led by Dr. Esther Toes-Zoutendijk from the Department of Public Health, Rotterdam University Medical Center, ERASMUS MC, Rotterdam, The Netherlands.

Limitations:

Study authors reported no limitations.

Disclosure:

Study authors report no relevant financial relationships.

Unified European Gastroenterology (UEG) Week 2023: Summary of LB08. Announced on October 16, 2023.

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