Photo credit: Md Babul Hosen
The following is a summary of “Anal Cancer in Previously Screened and Unscreened Patients: Tumor Stage and Treatment Outcomes” published in the January 2024 issue. Department of Gastroenterology by walker, other.
People at high risk for anal squamous cell carcinoma are recommended to undergo a targeted screening program. However, the evidence for these programs is not yet clear. For the study, researchers found that when high-risk patients (primarily those with HIV) were screened for squamous cell carcinoma, squamous cell carcinoma was detected earlier than when no screening was performed. I tried to find out if. It was a group study. Participants were included if they were at least 18 years old and had invasive anal squamous cell carcinoma between 2002 and 2022.
People identified through high-risk screening programs were compared to those who were not screened. The primary outcome was clinical stage at presentation, classified as T1N0M0 or other. Treatment received, treatment failure, and survival prolongation were examples of secondary outcomes. The study involved 612 people with anal squamous cell carcinoma, 26 of whom were detected through a screening program. Patients whose cancer was detected by testing were more likely to have her T1N0M0 tumor than those who were not tested (18 [69.2%] versus 84 [14.3%]; adjusted OR 9.95; 95% CI, 3.95 to 25.08). Sensitivity analyzes matched by propensity score had the same results (OR 11.13; 95% CI, 4.67 to 26.52).
Those who were screened were more likely to be treated with wide local excision alone than with a combination of chemotherapy, radiation therapy, and surgery (3) [12.5%] versus 18 [3.2%]; or 4.38; 95% CI, 1.20–16.04). Treatment failure or all-cause mortality was not statistically significantly different between groups. For people who are at high risk of developing anal squamous cell carcinoma, early detection of anal squamous cell carcinoma through screening can be helpful. Additionally, patients whose cancer was detected during cancer screening were more likely to receive only a wide local excision, which may have alleviated the pain and suffering associated with chemoradiotherapy and abdominoperineal resection. .
sauce: Journal.lww.com/dcrjournal/abstract/2024/01000/anal_cancers_in_previously_screened_versus.7.aspx