New study identifies potential therapeutic targets for colon disease
Top photo: Neuropilin 2 (Nrp2, green) is prominently distributed in longitudinal and circular colonic smooth muscle. The colocalization shown in the merged image indicates that Nrp2 is also expressed in Cajal’s stromal cells and is associated with type III receptor tyrosine kinase cancer biomarker (c-Kit), platelet-derived growth factor receptor Characterized by alpha (PDGFRa) positive cells […]
Research identifies promising treatment for advanced colorectal cancer
An international phase 3 clinical trial showed that patients with metastatic colorectal cancer who carry a rare genetic tumor mutation called KRAS G12C received a combination of the KRAS inhibitor sotorasib and the monoclonal antibody panitumumab compared to standard treatment. It was found that an excellent progression-free survival rate was achieved. City of Hope is […]
Next-generation sequencing identifies thousands of cancer patients who cannot receive immunotherapy
Brigham researchers’ next-generation sequencing findings suggest that updating current cancer treatment guidelines could allow approximately 6,000 more patients in the United States to benefit from immunotherapy treatment each year. suggests Immunotherapy is a highly effective treatment for patients whose cancer has mismatch repair defects, and new research identifies more cancer patients who could benefit from […]