New study identifies potential therapeutic targets for colon disease
Top photo: Neuropilin 2 (Nrp2, green) is prominently distributed in longitudinal and circular colonic smooth muscle. The colocalization shown in the merged image indicates that Nrp2 is also expressed in Cajal’s stromal cells and is associated with type III receptor tyrosine kinase cancer biomarker (c-Kit), platelet-derived growth factor receptor Characterized by alpha (PDGFRa) positive cells […]
Potential biomarkers of perforated appendicitis show association with severe sepsis
Machine learning enabled researchers to identify genetic biomarkers to predict perforated appendicitis in children with suspected appendicitis, according to a single-center prospective exploratory diagnostic study. Whole blood transcriptome analysis of 71 children reveals four genetic signatures that predict perforated rather than simple appendicitis with 85.7% accuracy, says Dr. Robert Hancock of the University of British […]
First-in-class targeted therapy has potential for colon cancer
Germany’s Merck KGaA (MRK:DE) announced a licensing agreement with New York-based small molecule developer Inspirna. The agreement is for ompenacrid, a first-in-class SLC6A8 blocker, and will also include other similar follow-on compounds. Omphenacrid is currently being evaluated in a Phase II trial for second-line treatment of certain people with advanced or metastatic colorectal cancer (mCRC). […]
Study points to potential use of cholesterol-lowering drugs to treat aggressive colorectal tumors
Hard-to-detect colorectal precancerous lesions known as serrated polyps and the aggressive tumors that develop from them are linked to increased production of cholesterol, according to preclinical studies by Weill Cornell Medicine researchers. It depends a lot. This finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors. In the study, […]
Giant villous adenoma of the rectum with cuous prolapse: a case report Although colorectal polyps are often adenomas and are more common in the elderly, villous adenomas are a subset that deserves attention due to their potential.
Giant villous adenoma of the rectum with cuous prolapse: a case report Although colorectal polyps are often adenomas and are more common in the elderly, villous adenomas are a subset that deserves attention due to their potential.
Giant villous adenoma of the rectum with cuous prolapse: a case report Although colorectal polyps, often adenomas, are common in the elderly, villous adenomas are a subset worthy of attention due to their potential. …2 hours ago
Giant villous adenoma of the rectum with cuous prolapse: a case report Although colorectal polyps, often adenomas, are common in the elderly, villous adenomas are a subset worthy of attention due to their potential. …2 hours ago
Cureus Latest Diagnosis of Acute Appendicitis CT Standards: Wall Thickness and Intraluminal Fluid Thickness Acute appendicitis is an epidemic disease that requires accurate and timely diagnosis and management to avoid potential complications . .4 days ago
Cureus Latest Diagnosis of Acute Appendicitis CT Standards: Wall Thickness and Intraluminal Fluid Thickness Acute appendicitis is an epidemic disease that requires accurate and timely diagnosis and management to avoid potential complications . .4 days ago
Cureus Latest Diagnosis of Acute Appendicitis CT Standards: Wall Thickness and Intraluminal Fluid Thickness Acute appendicitis is an epidemic disease that requires accurate and timely diagnosis and management to avoid potential complications . .4 days ago
Cureus Latest Diagnosis of Acute Appendicitis CT Standards: Wall Thickness and Intraluminal Fluid Thickness Acute appendicitis is an epidemic disease that requires accurate and timely diagnosis and management to avoid potential complications . .4 days ago
Cureus Omental infarction mimicking acute appendicitis: a case report Acute abdominal pain is a common presentation in the emergency department and is often attributed to a myriad of potential causes.
Cureus Omental infarction mimicking acute appendicitis: a case report Acute abdominal pain is a common presentation in the emergency department and is often attributed to a myriad of potential causes.
New study reveals potential treatment benefits
Image: : Neuropilin 2 (Nrp2, green) is prominently distributed in longitudinal and circular colonic smooth muscle. The colocalization shown in the merged image indicates that Nrp2 is also expressed in Cajal’s stromal cells and is associated with type III receptor tyrosine kinase cancer biomarker (c-Kit), platelet-derived growth factor receptor Characterized by alpha (PDGFR) positive cells, […]