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Non-alcoholic fatty liver Results from a large study show that NAFLD is an independent risk factor for precancerous colorectal adenomatous polyps in men and women.
methodology:
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Researchers retrospectively examined medical records of adults who underwent abdominal ultrasound; colonoscopy The study was conducted at a single hospital in China from January 2018 to December 2022 to investigate NAFLD status and the presence of polyps.
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Multivariate logistic regression analysis was used to detect the association between NAFLD and adenomatous and non-adenomatous polyps.
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Overall, 36.6% of 3,028 patients had adenomatous polyps, 10.7% had nonadenomatous polyps, and 52.7% had no polyps.
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The higher frequency of NAFLD was significant in adults with adenomatous polyps (66.9%) but not in patients with non-adenomatous polyps (57%) and adults without polyps (52.3%).
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In fully adjusted models, NAFLD was a significant independent risk factor for adenomatous polyps (odds ratio) [OR]1.6; P < .0001), but not for nonadenomatous polyps (OR, 1.0; P = .813).
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The association between NAFLD and adenomatous polyps was statistically significant in both men (OR, 1.8) and women (OR, 1.4).
in fact:
“Our results clearly showed that NAFLD is associated with the development of colorectal adenomatous polyps in men and women, but not with an increased risk of non-adenomatous polyps. This finding , provides new insights into the prevention of colorectal adenomatous polyps.” colorectal cancer “in patients with NAFLD,” the authors write.
sauce:
The study was co-led by Yingxue Yang and Yajie Teng from Kunshan First People’s Hospital, Suzhou, China.it was Published online August 23rd European Journal of Gastroenterology and Hepatology. This study received no specific funding.
Limitations:
The diagnosis of NAFLD was made by ultrasound rather than liver biopsy. The cross-sectional design of this study does not allow conclusions about a causal relationship between NAFLD and risk of colorectal adenomatous polyps. This study involved a single center.
Disclosure:
The authors disclose no conflicts of interest.
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